Profile of Paul Jurasz, PhD
Assistant Professor
Faculty of Pharmacy and Pharmaceutical Sciences
6152 Dentistry/Pharmacy Centre
University of Alberta
(780) 492-2120
Research
Pharmacology of Platelet-derived Angiogenesis Regulators
Platelets contain abundant pro- and anti-angiogenic mediators which help regulate angiogenesis. In my laboratory we study the pharmacological regulation of platelet-derived angiogenesis mediators in an attempt to inhibit growth of blood vessels to tumors and to promote therapeutic blood vessel growth for cardiovascular disease. Specifically, we are investigating the role of platelet-derived angiostatin plays in limiting angiogenesis, and how its production is regulated by serine and matrix metalloproteinases. Further, we are interested in how nitric oxide and protein kinase C signaling pathways influence the release of angiogenesis regulators from platelets.
For our studies the laboratory techniques that we use include platelet aggregometry, flow cytometry, microscopy, immunoblot, zymography, PCR, and various angiogenesis and endothelial cell migration assays.
- Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials.
Jurasz P, Courtman D, Babaie S, Stewart DJ.
Pharmacol Ther. 2010 Apr;126(1):1-8. Epub 2010 Feb 1. Review.
PMID: 20117135 [PubMed - indexed for MEDLINE]
- Elevated platelet angiostatin and circulating endothelial microfragments in idiopathic pulmonary arterial hypertension: a preliminary study.
Jurasz P, Ng D, Granton JT, Courtman DW, Stewart DJ.
Thromb Res. 2010 Jan;125(1):53-60. Epub 2009 May 9.
PMID: 19427678 [PubMed - indexed for MEDLINE]
- Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects on angiogenesis.
Jurasz P, Santos-Martinez MJ, Radomska A, Radomski MW.
J Thromb Haemost. 2006 May;4(5):1095-106.
PMID: 16689764 [PubMed - indexed for MEDLINE]
- Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation.
Jurasz P, Alonso-Escolano D, Radomski MW.
Br J Pharmacol. 2004 Dec;143(7):819-26. Epub 2004 Oct 18. Review.
PMID: 15492016 [PubMed - indexed for MEDLINE] Free PMC Article
- Generation and role of angiostatin in human platelets.
Jurasz P, Alonso D, Castro-Blanco S, Murad F, Radomski MW.
Blood. 2003 Nov 1;102(9):3217-23. Epub 2003 Jul 10.
PMID: 12855585 [PubMed - indexed for MEDLINE] Free Article
- Nonremodeling properties of matrix metalloproteinases: the platelet connection.
Jurasz P, Chung AW, Radomski A, Radomski MW.
Circ Res. 2002 May 31;90(10):1041-3. No abstract available.
PMID: 12039792 [PubMed - indexed for MEDLINE] Free Article
- Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.
Jurasz P, Sawicki G, Duszyk M, Sawicka J, Miranda C, Mayers I, Radomski MW.
Cancer Res. 2001 Jan 1;61(1):376-82.
PMID: 11196190 [PubMed - indexed for MEDLINE] Free Article
- VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells.
Jurasz P, Yurkova N, Kirshenbaum L, Stewart DJ.
Angiogenesis. 2011 Feb 13. [Epub ahead of print]
PMID: 21318419 [PubMed - as supplied by publisher]
